THE BALANCE BETWEEN THE INTERDEPENDING ELEMENTS OF CANNABINOIDS AND THE HUMAN MIND

Article translated into Italian. Below in the original English language.

Cannabinoids act considerably in the human body. They are responsible for transmitting the signal to the cannabinoid receptors of the endocannabinoid system, often working to achieve a stable equilibrium between the interdependent element.

From an evolutionary point of view, the cannabinoid signaling system is ancient and is found in invertebrates and in high-level vertebrate organisms. The endocannabinoid system has four main elements:

(1) CB1 and CB2 cannabinoid receptors coupled to G proteins

(2) Endogenous endocannabinoids that affect these receptors and possibly other receptors

(3) Enzymes that catalyze the biosynthesis and metabolism of endocannabinoids

(4) Mechanisms involved in the accumulation of specific endocannabinoid cells

Cannabis and homeostasis

Interestingly, the substances derived from semi and cannabis plants have been shown to significantly influence homeostasis within the body. They can both reduce and improve the action of specific systems, ultimately working as a biological regulator. The cannabinoids partly achieve these effects by working on the endocannabinoid system (ECS), a system composed of enzymes, signaling lipids and G protein coupled receptors known as CB1 and CB2 receptors.

Cannabinoids interact with these receptors because of their fundamental similarity with the molecules formed inside the organism known as endocannabinoids, chemical substances that also play a crucial role in homeostasis.

Homeostasis is defined as the inclination towards a relatively stable equilibrium between interdependent elements, with the exception of what is reserved by physiological processes. Homeostasis is a state of biological balance within the body. The external instances that cause the release of stress hormones such as heat and cold and internal alterations such as blood pressure and acidity, all physiological trigger the information passed later in the body that bring it back to equilibrium. These processes always occur and are vital for the survival of the body.

Cannabinoid receptors
The CB1 receptor is indicated in the brain and superficial tissues. In both areas, it has more features. In mind, it is the most abundant of the receptors coupled to the G protein and media the majority, if not all the psychoactive effects of THC. Its distribution is consistent with the pharmacology of marijuana.

Cb1 receptors
CB1 receptors develop in the cerebellum - knowledge and coordination, the hippocampus - learning and memory, cortex - cognitive and executive function and control and, synthesis of sensory inputs, basal ganglia planning, motor control, the ventral striatum - the prediction and reward feeling, Amygdala - fear, anxiety and emotion, the hypothalamus - hormone levels, appetite, sexual behavior, brainstem and marrow spinal.

Cb2 receptors
CB2 receptors are excellent on the outside, on immune cells, hematopoietic systems and other areas. There is an indication of the representation of the CB2 receptor in the brain. In mind, CB2 receptors also modulate the discharge of chemical signals mainly involved in immune system functions. CB2 receptors are of great interest because all the psychoactive effects of THC in humans can be reversed by selective CB1 receptor antagonism, implying that CB2 THC activation does not provide psychoactive effects. Subsequently, CB2 receptors are probably the target for drugs because they could avoid the adverse effects promulgated by cannabis or THC that induce psychoactive effects through CB1 receptors.

Endocannabinoids and signaling
Endocannabinoids act as a significant role in the regulation of pleasure, memory, thought, concentration, body movement, consciousness, appetite, pain and neural processing (hearing, smell, taste, touch and sight ) and brain development. The endocannabinoids acting on CB1 receptors (and possibly on CB2 receptors) modulate and "tune" indicating in most regions of the brain, to allow the brain to adapt to signals generated from multiple sources.

The purpose of the endocannabinoid system in the brain
Recognizing the multiple roles of endocannabinoid signaling in the brain allows us to understand the pharmacological effects of cannabis and other exogenous cannabinoids, their therapeutic potential and undesirable side effects. The study investigates the "on demand" endocannabinoid modulation of excitatory and inhibitory synaptic delivery and of regulatory functions in the brain.

Brain development
Endocannabinoid signaling is vital for brain development and drives the survival and generation of neural stem cells, the arrangements of cell fate and the motility and differentiation of subsequent neuronal and glial cells. Evolutionary endocannabinoid signaling, from the fetus to the young adult, may be sensitive to cannabis use during pregnancy and adolescence, probably influencing the structure and function of the brain. Endocannabinoids and the signaling of endocannabinoids altered by cannabis can provide neuropsychiatric diseases of developmental origin and in which changes to the signaling such as autism, bipolar disorder, schizophrenia and depression have been observed. The main role of the cannabinoid system in promoting adult neurogenesis in the hippocampus and lateral ventricles provides information on the mechanisms of neurogenesis underlying development in the mammalian brain. Both the THC that the CBD inhibit neurogenesis in the brains of adolescent or adult rodents, a mode of implicit relevance for a wide range of antagonistic events induced by cannabis.

The hypothalamus
Various physiological systems work in harmony to help the body reach homeostasis. The hypothalamus is an organ located in the brain, responsible for maintaining this balance. The hypothalamus connects the endocrine system and the nervous system and provides the release and inhibition of hormones that lead to hormone information passed subsequently throughout the body.

The endocannabinoid system is present in the hypothalamus, where it acts as a regulatory role in maintaining equilibrium or homeostasis, supporting the modulation of food intake and energy metabolism.

Cannabis to maintain balance
Cannabinoids from seeds of Nirvana they can bind to the cannabinoid receptors and maintain the balance of the mind and the human body. Let's take a look at patients with chronic pain. THC is not only an analgesic, but also blocks pain from inciting cannabinoid receptors that cause increased heart rate, blood pressure, mood effects and sleep deprivation.

Natalie Gray is a biochemical engineer. He works in the Research and Development team that deals with the design and construction of unitary processes. She is an avid supporter of marijuana and her love of organic chemistry has led her to medical cannabis. He grows his flowers, works on different projects and studies cannabis plants from the roots to the tops.

THE LINKING EQUILIBRIUM BETWEEN THE INTERDEPENDENT ELEMENTS OF CANNABINOIDS AND THE HUMAN MIND

The cannabinoids act remarkably in the human body. Cannabinoid receptors' signal of the endocannabinoid system, often working to achieve a steady equilibrium between the interdependent element.

Invertebrates and high-level vertebrate organisms. The endocannabinoid system has four principal elements:

(1) G protein-coupled cannabinoid CB1 and CB2 receptors

(2) Endogenous endocannabinoids that target these receptors, and possibly other receptors

(3) Enzymes that catalyze endocannabinoid biosynthesis and metabolism

(4) Mechanisms involved in cell accumulation of specific endocannabinoids

Cannabis And Homeostasis
Interestingly, substances derived from the cannabis seeds and plant have been shown to affect homeostasis within the body significantly. They can be bothers and enhance the action of specific systems, ultimately working as a biological regulator. Cannabinoids obtain these effects in part by working on the endocannabinoid system (ECS), a system composed of enzymes, signaling lipids, and G-protein coupled receptors known as the CB1 and CB2 receptors.

Cannabinoids interact with these receptors two to their fundamental similarity with molecules formed within the body known as endocannabinoids, chemicals that also play a crucial role in homeostasis.

Homeostasis is defined as the inclination towards a stable stable equilibrium between interdependent elements, except as reserved by physiological processes. Homeostasis is a state of biological equilibrium within the body. External issues that cause the release of stress hormones, as well as internal changes, such as blood pressure and acidity, all physiologically triggered into the equilibrium. These processes are occurring all the time and are vital to the survival of the body.

Cannabinoid Receptors
The CB1 receptor is signified in the brain and surface tissues. It has multiple features in both areas. It is the most abundant of the G-protein coupled receptors and mediates most, if not all the psychoactive effects of the THC. Its distribution is consistent with the pharmacology of marijuana.

Cb1 Receptors
CB1 receptors are developed in the cerebellum- the knowledge and coordination, Hippocampus- the learning and memory, Cortex- the cognitive and executive function and control, and the synthesis of sensory input, Basal ganglia- planning, motor control, ventral Striatum- the prediction and feeling of reward, Amygdala- the fear, anxiety, and emotion, Hypothalamus- the hormone levels, appetite, sexual behavior, brainstem and spinal cord.

Cb2 Receptors
CB2 receptors are excellent in the outside, on immune cells, hematopoietic systems, and other areas. CB2 receptor representation in the brain In mind, CB2 receptors also modulated the discharge of chemical signals principally involved in immune system functions. CB2 receptors are of concern concerning the psychoactive effects of THC in humans can be reversed by the selective antagonism of the CB1 receptor, implying that THC activation of CB2 does not provide psychoactive effects. Subsequently, CB2 receptors are promised by cannabis or THC that induces psychoactive effects via CB1 receptors.

Endocannabinoids And Signaling
Endocannabinoids act as a significant role in regulating pleasure, memory, thinking, concentration, body movement, consciousness, appetite, pain, and neural processing (hearing, smell, taste, touch, and sight), and brain development. endocannabinoids acting at CB1 receptors (and possibly CB2 receptors) modulated and "tune-up" showing in most brain regions.

The Purpose Of The Endocannabinoid System In The Brain
Insulin into the pharmacological effects of cannabis and other exogenous cannabinoids, their therapeutic potential and unwanted adverse effects. The study details in depth "on demand" endocannabinoid modulation of excitatory and inhibitory synaptic delivery and regulatory functions in the brain.

Brain Development
Endocannabinoid signaling is vital for the brain development and guides neural stem cell survival and generation, cell fate and the motility and differentiation of succeeding neuronal and glial cells. Developmental endocannabinoid signaling, from fetus to young adult, may be affecting brain structure and function. Endocannabinoids and cannabis-altered endocannabinoid signaling may provide to neuropsychiatric diseases that are of developmental roots and in which changes to signaling have been observed such as autism, bipolar disorder, schizophrenia, and depression. The first role of the cannabinoid system in promoting adult neurogenesis in the hippocampus and the lateral ventricles gives insight into the means of underlying post-developmental neurogenesis in the mammalian brain. Both THC and CBD inhibit neurogenesis in adolescent or adult rodent brain, a way of implied relevance to a wide range of cannabis-induced antagonistic events.

The Hypothalamus
Various physiological systems work in harmony to help the body achieve homeostasis. Hypothalamus is responsible for maintaining this balance. Hypothalamus links the endocrine system and the nervous systems and releasing the hormones that lead to the successively passed hormonal information throughout the body.

The Endocannabinoid system is present in the hypothalamus, where it acts as a regulatory role in maintaining the balance or homeostasis, supporting food intake and energy metabolism.

Cannabis For Keeping The Equilibrium
Cannabinoids from Nirvana seeds can bind to cannabinoid receptors and keep the equilibrium of the human mind and body. Let's look at patients with chronic pain. THC is not only an analgesic, but it also blocks the pain from the cannabinoid receptors that are triggering the increased heart rate, blood pressure, mood effects, and sleep deprivation.

Natalie Gray is a Biochemical Engineer. She works in the research and development team that focuses on the design and construction of unit processes. She is a recreational marijuana supporter and her love for organic chemistry brought her to medical cannabis. She grows her own flowers, working on different projects and studying everything above and under cannabis roots.